Traditional Chinese medicine has specific effect on some chronic diseases in clinic, especially in rheumatic diseases. Tripterygium wilfordii Hook (TWH) is a traditional Chinese medicine commonly used in the treatment of rheumatoid arthritis (RA); the unique therapeutic effect has been confirmed by a large number of research papers. TWH has many compounds that lead to its active compounds. However, the potential targets and pharmacological and molecular mechanism of its action treatment of rheumatic diseases are not entirely clear. Therefore, the network pharmacology approach is needed to further study and explore its treatment mechanism. We have successfully set up 10 networks, including four major networks and other networks. Four major networks include rheumatoid arthritis disease network, compound-compound target network of TWH, TWH compound target-rheumatoid arthritis disease network, and TWH-rheumatoid arthritis disease-mechanism network. Other networks consist of RA disease and TWH related targets clusters, biological processes, and pathways network. Our study successfully predicted, explained, and confirmed the TWH of RA disease molecular synergy and found the potential of RA related targets, cluster, biological process, and pathways. This study not only provides prompts to the researcher who explores pharmacological and biological molecular mechanism of TWH applying to RA disease, but also proves a feasible method for discovering potential activated compounds from Chinese herbs.

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Tuberculosis (TB) is caused by mtb infection and has posed great threats to public health (W.H.O & Global tuberculosis report, 2020). Due to long treatment periods, drug resistance, and various side effects, TB's global threats have been exacerbated in recent years (Nadaf et al., 2020). Various efforts have been made in the new strategies to fight TB, but only two new drugs have recently been approved for clinic use (Furin et al., 2019;Ribeiro et al., 2020). Therefore, it is imperative to discover new anti-TB drugs, and develop new strategies for the prevention and treatment of TB.