Gastric cancer remains the main cause of cancer death all around the world, and upregulated activation of the nonreceptor tyrosine kinase c-SRC (SRC) is a key player in the development. In this study, we found that expression of Src is also increased in clinical gastric cancer samples, with the protein level increased more significantly than that at the RNA level. Further study revealed that miR34a and miR203, two tumor suppressive miRNAs, inversely correlate with the expression of Src. Restoration of miR34a and miR203 decreased Src expression in gastric cancer cell lines, which in turn inhibited cell growth and cell migration. In summary, our study here revealed that posttranscriptional regulation of Src contributes to the deregulated cell growth and metastasis in gastric cancer, and targeting Src by miR34a or miR203 mimics would be a promising strategy in therapy. [BMB Reports 2013; 46(6): 316-321]

In the tension leveling process, calculation of the strip elongation by the traditional method only considers the extension rate after the tension response, while ignoring elastic bending recovered, so the calculation of elongation is large enough to affect the process control accuracy. This paper considers not only the residual strain after elastic bend recovery, but also the affection of the residual deformation under plain cross-section assumption. The calculation of the elongation is less 4-10% than that of the traditional one. It shows that parameters of the tension leveling process set by the new method will be calculated accurately.

Sulfhydryl lignin was prepared by immobilizing sulfhydryl onto wood lignin. The effect of pH, temperatμre, adsorption time, salinity of condiment and amino acid concentration of condiment on the adsorption behavior of sulfhydryl lignin was investigated, respectively. The adsorption kinetics and thermodynamics of Cu(Ⅱ) were also studied.

Confronting the problem that echnology parameters are difficult to set in the strip tension levelling process, in this paper takes the tension leveler as research object, using the ANSYS software to make dynamic simulation of strip tension levelling process, mainly analyse relationship between the intermesh and curvature, get result that curvature radius during the straightening process is much larger than bending roller radius, as well as the relationship between curvature and the intermesh under the specific structure condition, the research provides help for the optimization of the tension leveler equipment technology parameters.

In this paper, we present a new approach to improve extracting accuracy of impervious surfaces. One Landsat TM image of Taiyuan city, Shanxi Province of China was used. After doing test work and analyzing using optimum bands analysis, principal component analysis, and normalized difference impervious surface index, we present the method, optimized band combination. Both unsupervised and supervised classification methods were used to classify the original image, principal component analysis image, normalized difference impervious surface index image, and optimized band combination images we present. The accuracies result of these classifications were assessed by using 256 randomly selected sampling points, and it was found that the overall accuracy the accuracy of optimized band combination method can be reach 87.72%, with the Kappa statistic of 0.85 in impervious surface extraction, it was better than other three methods can get.