A double-folding method is used to calculate the nuclear and Coulomb interaction between two deformed nuclei with arbitrary orientations. A simplified Skryme-type interaction is adopted.The contributions of nuclear interaction and Coulomb interaction due to the deformation and orientation of the nuclei are evaluated for the driving potential used in the description of heavy-ion fusion reaction. So far there is no satisfactory theory to describe the evolution of the dynamical nuclear deformation and orientations during the heavy-ion fusion process. Our results estimated the magnitude of above effects.