Background Acute coronary syndrome (ACS) has become a vital disease with high mortality in the Uygur populations. Clopidogrel plays an important role in reducing the risk of recurrent cardiovascular events after ACS; however, it is a prodrug that requires biotransformation by cytochrome P450 (CYP450). Objectives To determine the effect of genetic polymorphisms in CYP2C19*2, *3, and *17, and along with clinical, demographic factors, on variation in response to clinical outcomes in Uygur patients. Methods A total of 351 patients with ACS were treated with clopidogrel and aspirin for at least 12 months; we recorded major adverse cardiovascular events (MACE) or bleeding within 1 year. Multivariable logistic regression analyses were carried out to identify factors associated with MACE or bleeding. Results We analyze risk factors include age, BMI (body mass index), smoking, alcohol intake, NSTEMI (non-ST-segment elevation myocardial infarction), hypertension, dyslipidemia, concomitant medication, CYP2C19*2 carriers, CYP2C19*17 carriers and metabolizer phenotype. CYP2C19*2 carriers had an odds of having MACE of 2.51 (95% CI: 1.534–4.09) compared with noncarriers (P < .001). However, no factors were significantly associated with bleeding (P > 0.05). Conclusion The CYP2C19*2 gene polymorphism contributes to the risk of MACE in dual clopidogrel—treated Uygur population with ACS with or without PCI (percutaneous coronary intervention). These data may provide valuable insights into the genetic polymorphisms affecting clopidogrel metabolism among minority groups in China.

Combined cooling, heating and power system (CCHP) can realize the cascade utilization of energy and improve the energy utilization efficiency. Focusing on the phenomenon that the traditional self-sufficiency mode is easy to cause insufficient or excess regional energy supply, considreing the complementarity between different regional load characteristics, an internal multi-region interconnected complementary energy supply method based on aggregator mode was proposed. In order to solve the problem of uncertainty in the optimal dispatching of multiple resources in the region under the aggregator mode, an optimal dispatching model based on interval linear programming was constructed, which took the minimum operation cost of aggregator as the objective function. The feasibility and effectiveness of the method are verified by analyzing the aggregator mode in residential area, commercial area, office area and industrial area. The results show that the operation cost can be reduced and the economic benefit can be improved under the aggregator mode.

Oxygen precipitate nucleation behaviors have been comparatively investigated in the heavily antimony (Sb)-doped and lightly phosphorus (P)-doped Czochralski silicon (CZ-Si) wafers subjected to the high temperature anneal at 1000 o C for 16 h following the nucleation anneal at 450, 650 or 750 o C for up to 64 h. It is found that in the heavily Sb-doped CZ-Si the oxygen precipitate nucleation at 450 or 750 o C is always suppressed, while that at 650 o C is hardly suppressed in the case of sufficient length of annealing. It is believed that oxygen precipitate nucleation based on the Sb-V complexes occurs at 650 o C, whereas, this is not the case at 450 or 750 o C. Therefore, oxygen precipitate nucleation at 650 o C is enhanced in the heavily Sb-doped CZ-Si. Moreover, it can be comparable to that in the lightly P-doped CZ-Si as the annealing time is long enough.

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