&ROOHJH RI &RPSXWHU 6FLHQFH DQG 7HFKQRORJ\ =KHMLDQJ 8QLYHUVLW\ +DQJ]KRX &KLQD (PDLO ^OHL[X JXR[LOL OLFKXDQ OXFN\ZHLMLH FKHQZ] ]MX]KZDQJ `#]MX HGX FQ $EVWUDFW²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rd IEEE International Conference on Mobile Cloud Computing, Services, and Engineering 978-1-4799-8977-5/15 $31.00

To study the influence of drug cocrystal on the solubility of active pharmaceutical ingredients (APIs). The ETZ·2TMA·MeOH cocrystal was obtained by the solution evaporation crystallization method. The cocrystal structure was characterized by Single Crystal X-ray Diffractometer. The single crystal belongs to orthorhombic crystal system with space group P212121(no.19), a = 12.9863(9) Å, b = 16.6603(11) Å, c = 25.9260(16) Å, V = 5609.2(6) Å3, Z = 8, T = 170.00 K. The main forces are the formation of intermolecular hydrogen bonds between the amide groups on ETZ and the carboxyl groups on TMA and the hydroxyl group on methanol. In addition, the solubility of ETZ and ETZ·2TMA·MeOH cocrystal was determined. The results show that, in contrast to most cocrystal systems that improve solubility, the solubility of ETZ·2TMA·MeOH decreased to 19.30 % of pure ETZ.

No abstract

C30H36F2N6O9S, orthorhombic, P212121 (no. 19), a = 5.2364(8) Å, b = 10.0250(14) Å, c = 59.689(9) Å, V = 3133.4(8) Å3, Z = 4, Rgt (F) = 0.0384, wRref (F 2) = 0.0969, T = 170 K.