h coupling bet.ween t,wo t,ransmission lines of finite length in arbit,rary directions is studied. The tra.nsmission line generates elec.troma.gnet,ic fields affecting the other line so that, the modified t,elegrapher's equation is adopted to analyze the phenomenon. One transmission line of finite length above a ground plane has risers at both line ends. Therefore t8he fields due to currents on t,he risers a.nd the line section should be taken a.ccount. A fourport net,work expression is obtained from a solut,ion to t,he modified t,elegrapher's equation. Validit,y of the theory is confirmed by experimental results for various models.
Background
Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor, was previously correlated with inflammation-related diseases. However, its function on intervertebral disc degeneration remains unclear.
Methods
A latex-enhanced immunoturbidimetric assay measured the serum level of AAT. Real-time polymerase chain reaction (RT-qPCR) and western blot were used to testify the expression of RNA and proteins related to cell apoptosis and the Wnt/β-catenin pathway. The animal model for intervertebral disc degeneration was built by disc puncture. The degeneration grades were analyzed by safranin o staining.
Results
We showed that alpha-1 antitrypsin could ameliorate intervertebral disc degeneration in vitro and in vivo. We also found that the serum alpha-1 antitrypsin level in Intervertebral disc degeneration patients is negative related to the severity of intervertebral disc degeneration. Moreover, alpha-1 antitrypsin was also showed to suppress tumor necrosis factor-alpha (TNF-α) induced WNT/β-catenin signaling pathway activation in human nucleus pulposus cells.
Conclusions
Our study provides evidence for AAT to serve as a potential therapeutic reagent for the treatment of intervertebral disc degeneration.
With the theoretical and technical progress of Wushu education, the traditional teaching method of oral instruction and demonstration can no longer satisfy the needs of current Wushu education. To address this issue, the concept and basic characteristics of virtual reality technology were interpreted, and the effective path and challenges of applying virtual reality technology in Wushu education. The results of this study show that virtual reality technology contributes to the concrete presentation of implicit knowledge in Wushu, the construction of virtual scenes in Wushu education and the realization of a simulated self-learning system in Wushu. In the meanwhile, the application of virtual reality technology in Wushu education faces the challenges of high virtual reality equipment investment, three-dimensional modeling difficulties, huge data volume of Wushu movements and side effects after the experience of Wushu, etc.
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