A photoredox and copper-catalyzed fluoroalkylphosphorothiolation of activated and unactivated alkenes via a radical relay mechanism is reported. By employing fluoroalkyl halides as radical precursors and P­(O)­SH or P­(S)­SH compounds as coupling partners, a wide range of β-monofluoroalkyl-, -difluoroalkyl-, -trifluoromethyl-, or -perfluoroalkyl-substituted S-alkyl phosphorothioates and phosphorodithioates can be easily constructed under mild conditions with good functional group tolerance. Furthermore, this modular reaction system can be successfully applied to late-stage functionalization of bioactive molecules.

Prostate cancer (PCa) is a common malignancy of reproductive system occurred in males (Groeben & Wirth, 2017;Saranyutanon et al., 2020). The factors that may lead to PCa include age, genetic background, race and diet (Rebbeck, 2017). The incidence rate of PCa remains the highest in most developed regions of the world as North America and Western Europe, while the mortality of PCa is investigated to be highest in African descent men (Mahal et al., 2020).With the adoption of prostate-specific antigen testing, the diagnosis of PCa becomes easier which temporarily increases the number of patients (Barry & Simmons, 2017;Welch & Albertsen, 2020). With an estimated death number of 307,000, PCa becomes the primary cause of 6.6% cancer mortality among males (Ferlay et al., 2015).Although the incidence and mortality are reduced in developed countries, the global trend indicates that PCa incidence is on the rise worldwide (Taitt, 2018). It is worth studying the molecular mechanism of PCa to improve the prognosis of PCa.Long noncoding RNAs (lncRNAs) belong to RNAs that participate in biological processes of cancer. LncRNAs are transcripts with over