Introduction: Kala-azar is one of the most neglected tropical infectious diseases. Malnutrition and Kala-azar are serious problems of public health significance, and most often exist together. Even though kala-azar remained endemic in Ethiopia, explicit data on the magnitude and factors associated with nutritional status of kala-azar patients are scarce. The study aimed to assess nutritional status and associated factors among adult kala-azar patients who were admitted in Kala-azar treatment centers of Northwest Ethiopia.