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A mild and practical protocol for the metal-free trifluoromethylation of styrenes using NaSO 2 CF 3 (Langlois reagent) and TBHP was developed. The approach provides efficient access to α-trifluoromethylated ketones and alcohols in moderate to good yields.

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A new approach that tried to obviate the use of bromine protection groups was studied to synthesize (−)‐renieramycin G from L‐tyrosine. It was found that the first intermolecular Pictet–Spengler reaction proceeded successfully to give the correct tetrahydroisoquinoline precursor 6. However, the second intramolecular Pictet–Spengler cyclization step failed to give the desired product, and an isomer of the skeleton of the renieramycins was obtained via 12 steps starting from L‐tyrosine. J. Heterocyclic Chem., (2011).