This paper investigated the mechanical properties of GQ-6 subjected to a tremendous amount of uniaxial tests. Such material is a new kind of ultra high molecular weight polyethylene fiber and aimed to be adopted in stratospheric airship. To begin with, mono-uniaxial tensile tests were conducted. The cycling-uniaxial tensile experiments were then carried out on the basis of the mono-uniaxial tensile tests data. Finally, performances of welding seams were thoroughly investigated with forty welding specimens. Results of mono-uniaxial tensile tests revealed that such woven fabric possesses high tensile strength and low elongation ratio at break. Meanwhile, the stress–strain behaviors were fitted by the Ogden model and a good agreement between such model and experimental data was obtained. Influences of the uniaxial loading cycle on such woven stiffness were discussed and the elastic moduli were defined with a standard hysteresis loop. For the welding tests, four types of overlapping welding failures were discovered. Compared with intact specimens, an appropriate welding width of 60 mm and an approximate 15% discount of the ultimate tensile stress on the intact textile were obtained.

Artificial neural network (ANN) is widely applied to the modeling of complex systems, which has become a common modeling method in the study of materials science. As the ideal candidates for high temperature structural materials, carbon materials are no doubt involved in fatigue loads, so the study on forecasting fatigue life is meaningful. In this paper, the electrical resistance at various fatigue cycles and level of applied stress of the materials under tensile fatigue loading has been detected, and regarded the fracture or fatigue cycles equal to 106 as fatigue life of carbon materials. On the basis of the electrical resistance value, the fatigue life has been forecasted by applied the ANN. The results indicated that the ANN could forecast the fatigue life of carbon materials well; finally, the applications of ANN in the study of material, such as properties prediction, damage prediction and failure detection were reviewed.

Rare inherited variations in multiplex families with Gilles de la Tourette syndrome (GTS) are suggested to play an important role in the genetic etiology of GTS. In order to explore the rare inherited variations with the risk of GTS, whole-exome sequencing (WES) was performed in a family with three affected patients with GTS. Among the five novel rare variations identified by WES, CLCN2 G161S was presented in three patients, but not in four unaffected individuals, and thus co-segregated with GTS. A validation study was also performed in a cohort of Chinses Han population to further examine the identified rare variants. CLCN2 G161S was genotyped in 207 sporadic patients with tic disorder including 111 patients with GTS and 489 healthy controls. Compared with that in controls [allele frequency (AF) = 0], CLCN2 G161S had higher variant AF in patients with tic (AF = 0.00483) and in patients with GTS (0.00900), respectively. However, this variant was absent from the current 1000 Genome databases, and the variant AF is very low in the current public databases including ExAC (AF = 0.00001) and gnomAD (AF = 0.00003). Our results suggest that CLCN2 G161S might play a major role in the genetic etiology of GTS, at least in a Chinese Han population.

Porous structure is an important component in C/C composites, which directly affects the fatigue behavior of materials. Therefore, it is necessary to discuss the evolution of porous structure in C/C composites under the fatigue loading. In present work, the character of porous structure in original C/C composites was summarized and the evolution of porous structure after fatigue loading was analyzed. The positive effect of the porous structure evolution after fatigue loading on the reinforcing behavior of fatigue was proposed as well, which could provide a basis for further studies on the fatigue mechanisms of C/C composites.

ObjectiveTo investigate the adaptability of Comprehensive Behavioral Intervention for Tics (CBIT) for a Chinese population, and evaluate the efficacy of combined CBIT and pharmacotherapy (CBIT + PT) compared to CBIT or pharmacotherapy (PT) alone for reducing tics and for improving the quality of life (QoL) in a sample of Chinese children with chronic tic disorders (CTD) and Tourette syndrome (TS).Materials and methodsIn this 10-week randomized controlled pilot trial, 37 outpatients aged between 6 and 16 years affected by TS and CTD were randomly assigned to receive CBIT (n = 22) or PT alone (n = 15). Considering the feasibility, the patients allocated to the CBIT treatment group could further choose whether to simultaneously take medicine voluntarily, resulting in a CBIT alone group (n = 12) and a CBIT + PT group (n = 10).ResultsAt baseline, no significant difference was found between the three groups in the demographic and clinical characteristics (p > 0.05). All three groups showed a significant reduction in tic severity after treatment assessed by the Yale Global Tic Severity Scale (YGTSS) severity score [F(2,33) = 35.05, p < 0.001, ηp2 = 0.51], the score of the Clinical Global Impression scale for Improvement (CGI-I) [F(1,34) = 13.87, p = 0.001, ηp2 = 0.29], and YGTSS impairment score [F(2,33) = 31.71, p < 0.001, ηp2 = 0.48]. Significant interactions were found between the time-point and group in emotional functioning [F(2,29) = 4.39, p = 0.02, ηp2 = 0.23], psychosocial functioning [F(2,29) = 5.93, p = 0.007, ηp2 = 0.29], and total QoL score [F(1,34) = 3.72, p = 0.04, ηp2 = 0.20] of Pediatric Quality of Life Inventory (PedsQL 4.0) for children suggesting a significantly larger improvement in emotional functioning, psychosocial functioning, and total QoL score of the life quality in the CBIT group for children self-report. PedsQL for proxy report only showed a significant main effect of time-point in physical functioning [F(1,33) = 8.35, p = 0.01, ηp2 = 0.2], emotional functioning [F(1,33) = 10.75, p = 0.002, ηp2 = 0.25], psychosocial functioning [F(1,34) = 11.38, p = 0.002, ηp2 = 0.26], and total Qol score [F(1,34) = 13.21, p = 0.001, ηp2 = 0.29].ConclusionCBIT is probably effective in reducing tic severity in Chinese children with tic disorders. CBIT + PT may not be superior to CBIT alone in reducing tic severity and improving quality of life. CBIT alone showed advantages in improving quality of life over CBIT + PT and PT alone. CBIT might be an appropriate treatment option for patients with tic disorder in Chinese mainland.