E-commerce has been extensively capitalized by big companies. However, little is known about the adoption of e-commerce by small and medium enterprises (SMEs). Many might do so to reap the efficiency of the internet to benefit their businesses. Thus, the study aims to investigate factors affecting adoption of e-commerce by SMEs in Melaka. Five dimensions, namely, Perceived Ease of Use, Security, Relative Advantage, Perceived Compatibility, and Top Management Support were drawn from Technology acceptance model and UTAUT. This research had adopted a quantitative research method that utilized questionnaires to collect data from SMEs in Melaka. About ninety-two percent of 219 questionnaires were collected. Results indicated that these dimensions were significant to influence the adoption of e-commerce among SMEs in Melaka. This finding is useful for SMEs and other organizations to understand what factors are important in making decision about adopting e-commerce. We recommend future researches to study on the behavioral aspect of ecommerce decisions and implementations.