For uremic patients, in whom creatinine level is high and many of them suffered from diabetes mellitus, serum creatinine can be either under- or overestimated by Jaffe method. Enzymatic method is less affected and may be a better method.

To the Editor: The article 'Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis' has great significance in clinical practice but needs to be interpreted with caution. 1 In this multicenter retrospective analysis the role of steroids in patients with biopsy-proven drug-induced acute interstitial nephritis was evaluated in 61 patients. The authors found that final serum creatinine values in patients who were treated with steroids, especially early in the course of disease were significantly lower than the untreated group. In this study patients were categorized as mild, moderate, and severe