In this paper, a pressure distribution sensing system based on wavelet analysis and resistance tomography is proposed to overcome the shortcomings of a traditional electrode type pressure distribution sensor, which needs to be arranged with many electrodes and has a high production cost. The system uses ADS1256, a constant current source module, a serial communication module, a Raspberry host, a touch screen, and other components. The wavelet transform is used to preprocess the collected signal to improve the anti-jamming performance of the system. The method of resistance tomography is used to realize the real-time imaging of pressure distribution. Finally, the reliability of the system is verified using conductive silica gel as a sensitive material. The experimental results show that wavelet analysis preprocessing can significantly improve the quality of pressure distribution imaging.