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An analog signal processing integrated circuit for micro-cantilever array is designed for strain measurement in biomedical applications. The chip includes an analog multiplexer, an instrumentation amplifier, a sample and hold circuit, an on-chip voltage and current reference, a successive approximation register analog-todigital converter and a digital control unit. The 8-bit ADC attains 45.4 dB signal-to-noise-and-distortion ratio and 56.4 dB spurious-free-dynamic-range while operating at 772 KHz. The chip occupies an area of 1.54 mm 2 and consumes 17.8 mW power with a single 3.3 V supply. The chip has been fabricated in a 0.35μm 2-poly 4-metal CMOS process technology. 2 SYSTEM OVERVIEW The system block diagram is shown in figure 2. The system can be partitioned into three parts based on