ÁC 7 H 5 O 4 À , and BZMD-3,5-dihydroxybenzoic acid (3/1), 3C 13 H 13 N 3 O 4 ÁC 7 H 6 O 4 , and their crystalline structures elucidated, confirming the robustness of the selected synthon.

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Salinaphthoquinones A–E (1–5) were isolated from a marine Salininispora arenicola strain, recovered from sediments of the St. Peter and St. Paul Archipelago, Brazil. The structures of the compounds were elucidated using a combination of spectroscopic (NMR, IR, HRESIMS) data, including single-crystal X-ray diffraction analysis. A plausible biosynthetic pathway for 1–5 is proposed. Compounds 1 to 4 displayed moderate activity against Staphylococcus aureus and Enterococcus faecalis with MIC values of 125 to 16 μg/mL.

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In contrast to the widespread polymorphism of single component drugs, polymorphism in cocrystals is still uncommon and often poorly understood. While there are numerous reports of polymorphic forms of single...