Implantable thermo-responsive drug-loaded magnetic nanofibers (NFs) have attracted great interest for localized thermo-chemotherapy of cancer tissue/cells. From this perspective, smart polymeric electrospun NFs co-loaded with magnetic nanoparticles (MNPs) and a natural polyphenol anticancer agent, curcumin (CUR), were developed to enhance the local hyperthermic chemotherapy against melanoma, the most serious type of skin cancer. CUR/MNPs-loaded thermo-sensitive electrospun NFs exhibited alternating magnetic field (AMF)-responsive heat generation and "ON-OFF" switchable heating capability. Besides, corresponding to the reversible alterations in the swelling ratio, the "ON-OFF" switchable discharge of CUR from the magnetic NFs was detected in response to the "ON-OFF" switching of AMF application. Due to the combinatorial effect of hyperthermia and release of CUR after applying an AMF ("ON" state) for 600 s on the second and third days of incubation time, the viability of the B16F10 melanoma cancer cells exposed to the CUR/MNPs-NFs was reduced by 40% and 17%, respectively.Taken together, the macroscopic and nanoscale features of the smart NFs led to the creation of a reversibly adjustable structure that enabled hyperthermia and facile switchable release of CUR for eradication of melanoma cancer cells.

At the end of 2019, the coronavirus disease 2019 (COVID-19) [1] spreads across the world [2]. Hubei Province has been one of the most affected areas in China. In response to the national call for medical personnel, the medical assistance team of Heilongjiang Province arrived at Wuhan Union Hospital right away. 6S [3] is a management model for enterprise operation that is derived from the 5S concept proposed by Hiroyuki Hirano [4]. The core of 5S includes Seiri, Seiton, Seiso, Seiketsu and Shitsuke. Years of practice have proven that 5S can significantly improve the efficiency and quality of corporate work, enhance corporate image and create a good working atmosphere. 6S adds the concept of security to the 5S model. While helping at the hospital, the nursing assistance team of Heilongjiang Province fully applied the concept of 6S to manage the team and achieved good results, such as zero infections among medical staff, zero nursing accidents and zero complaints from patients. The experience is summarized in this paper in the hope of helping in the global fight against the epidemic. Challenges in nursing As the medical assistance team was the first to arrive, no precedents had been set; thus, the following problems were encountered at the initial stage of their work:

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