No abstract

Mobile applications (apps) have become popular among consumers to facilitate their existing food practices like cooking, shopping, and dining out. However, the feasibility of using mobile apps to facilitate sustainability transitions in food consumption is not well researched. In this study, we, therefore, propose a conceptual framework to illustrate how mobile apps can be developed in linking everyday food practices with sustainability transitions. Through the case study of dining out and with the help of focus group discussions, we seek to illustrate that practice theory might serve as a useful starting point for understanding the dynamics of food practices, their relevant sustainability dimensions, and the ways in which mobile apps can be used for changing current food practices into more sustainable ones. Among our main results are the findings that consumers prefer the sustainability food app to be integrated with dominant or mainstream apps, which are already used by consumers in the context of dining out. Besides being simple, functional, flexible, and rewarding, the information provided by the app should be reliable and trustworthy. Moreover, both science-based and practice-based information is necessary to provide sufficient guidance to consumers on how changes in food practice can be operationalized and implemented.

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Abdominal aortic aneurysm (AAA) is usually asymptomatic until life-threatening complications occur, predominantly involving aortic rupture. Currently, no drug-based treatments are available, primarily due to limited understanding of AAA pathogenesis. Transcriptional regulator PR domain-containing protein 16 (PRDM16) is highly expressed in the aorta, but its functions in the aorta are largely unknown. By RNA-seq analysis, we found that VSMCs-specific Prdm16 knockout mice (Prdm16 SMKO ) already showed extensive changes in the expression of genes associated with extracellular matrix (ECM) remodeling and inflammation in the abdominal aorta under normal housing conditions without any pathological stimuli. Human AAA lesions displayed lower PRDM16 expression. Periadventitial elastase application to the suprarenal region of the abdominal aorta aggravated AAA formation in Prdm16 SMKO . During AAA development, VSMCs undergo apoptosis because of both intrinsic and environmental changes including inflammation and ECM remodeling. Prdm16 deficiency promoted inflammation and apoptosis in VSMCs. A disintegrin and metalloproteinase 12 (ADAM12) is a gelatinase which can degrade various ECM. We found that ADAM12 is a target of transcriptional repression by PRDM16. Adam12 knockdown reversed VSMC apoptosis induced by Prdm16 deficiency. Our study demonstrated that PRDM16 deficiency in VSMCs promoted ADAM12 expression and aggravates AAA formation, which may provide potential targets for AAA treatment.

No abstract