Background: The nuclear division cycle 80 (NDC80) complex assures proper chromosome segregation during the cell cycle progression. SPC25 is a crucial component of NDC80, and its role in hepatocellular carcinoma (HCC) has been explored recently. This study characterized the differential expression of SPC25 in HCC patients of different races and HBV infection status. Methods: Expression patterns of SPC25 were evaluated in TCGA and Chinese HCC patients. Kaplan-Meier analysis was applied to examine the predictive value of SPC25. In vitro and in vivo functional assays were conducted to explore the role of SPC25 in HCC. Bioinformatics methods were applied to investigate the regulatory mechanisms of SPC25. Findings: The mRNA levels of SPC25 were up-regulated in HCC. SPC25 has a significantly higher transcriptional level in Asian patients than Caucasian patients. SPC25 promoted HCC cell proliferation in vitro and tumor growth in vivo by accelerating the cell cycle. We identified transcription factors, miRNAs, and immune cells that may interact with SPC25. Interpretation: The findings suggest that increased expression of SPC25 is associated with poor prognosis of HCC and enhances the proliferative capacity of HCC cells. SPC25 could serve as a valuable prognostic marker and a novel treatment target for HCC.

Blockchain technology is regarded as a disruptive technology with real potential for change after steam engine, electricity and Internet, and it has huge advantages. Both blockchain and energy internet are technically decentralized, highly autonomous, market-oriented and intelligent, and thus show strong application potential. Distributed trading is the most important application of blockchain technology in the field of smart energy. Under the premise of summarizing the basic principles and application scenarios of blockchain, this paper analyzes the weakly centralized internal bidding energy business model of intelligent micro grid based on blockchain technology. This mode utilizes multi-party bidding to optimize the allocation of resources such as cold, heat and electricity, restore the commodity and financial attributes of energy, and can greatly improve the energy efficiency and economic benefits of micro grid.

This paper proposes a research perspective of energy blockchain based on the three-dimensional attributes of physics-information-value: analyzes the coupling between blockchain technology and energy Internet in the dimensions of physics, information, and value under complex network systems, and proposes a physical-information-value-based research perspective. The basic framework of energy blockchain from a three-dimensional perspective of information-value, and in-depth research on the main content of energy blockchain from the perspectives of physics, information and value, and finally designed an energy blockchain from a multi-dimensional comprehensive perspective with the energy microgrid as the scene. cooperative autonomous mode and its operation process.

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