Using a simple accelerating model and an assumption that γ‐rays originate from p–p collisions for a π0 model, we investigate γ‐ray sources like V407 Cygni in symbiotic stars. The upper limit of their occurrence rate in the Galaxy is between 0.5 and 5 yr−1, indicating that they may be important sources of high‐energy γ‐rays. The maximum energies of the accelerated protons mainly distribute around 1011 eV, and barely reach 1015 eV. The novae occurring in D‐type SSs with ONe white dwarfs and long orbital periods are good candidates for γ‐ray sources. Due to a short orbital period which results in a short acceleration duration, the nova occurring in symbiotic star RS Oph cannot produce γ‐ray emission like that in V407 Cygni.