Progesterone (P4) is an important biomarker of various diseases. When P4 level exceeds the normal value, the human body produces a series of problems, including carcinogenic risks. Developing the method for P4 monitoring with accurate, inexpensive, and fast becomes an important topic for researchers. In recent years, the abundance of new materials and synthesis technologies has developed P4 biosensors. Based on functional materials, this paper reviews the recent decade literatures and summarizes the latest progress and applications in enhancing detection of P4. In this study, the functional materials used to manufacture P4 biosensors are mainly divided into three categories: metal and metal-oxide nanomaterials, composite material, and other materials. A composite material refers to a combination of two or three types of materials, including carbonaceous nanomaterials, metal nanomaterials, polymers, and biological materials. The other materials mainly include a combination of special compounds, biomaterials, luciferin materials, and quantum dot materials, of which one or two. The introduction of these new functional materials improves the sensitivity and selectivity of P4 detection. Moreover, this study provides ideas for the future research on improving the performance of P4 biosensor. The future study should put more attentions on enzyme catalysis amplification, cyclic amplification, and DNA isothermal amplification strategies.
Superhydrophobic surfaces can be applied to environmental, energy, and healthcare fields. However, the weak durability issue has significantly limited the practical industrial applications. To overcome the readily destroyed interfacial structures and chemical compositions, the superhydrophobic surfaces with high mechanical and chemical durability have been created on a stainless steel mesh (SSM) as a protective frame based on tightly crosslinked polydimethylsiloxane (PDMS)−candle soot (CS) composite coatings through simple mechanical transfer and candle burning processes, which abbreviated to SSM/PDMS−CS and showed a water contact angle (WCA) of 159.4 ± 1.6° and a sliding angle (SA) of 2.3 ± 0.5°. Harsh abrasion examinations based on sandpaper and fiber paper have been conducted by applying 100 g weight and 200 cm sliding distance. And the obtained WCAs and SAs were 155 ± 3.7°, 155.7 ± 2° and 3.7 ± 0.5°, 3.5 ± 0.3°. Scanning electron microscope showed scratches on the surface, but the superhydrophobic property has been well maintained. After 40 kHz ultrasonication treatment for 30 min, WCA and SA were 152 ± 0.9° and 4.1 ± 0.8°. Finally, SSM/PDMS−CS surfaces exhibit good chemical resistance to corrosive solutions even after pH 2, pH 10, 1 M NaCl, and toluene treatments for 15 days.
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