Three previously undescribed seco-dammarane triterpenoid glycosides O-Q (1-3) along with two known compounds (4 and 5) were isolated and characterized from the leaves of Cyclocarya paliurus. Their structures were determined by comprehensive analysis of 1D, 2D NMR and HRESIMS data. Compounds 1-5 were evaluated for their inhibitory effects against human pancreatic tumor (ASPC-1), human gastric carcinoma (SNU5), liver hepatocellular carcinoma (HEPG-2) and human colon tumor (HCT116) cell

Vitamin D3 has been reported to be an immunity modulator and high levels of vitamin D3 are correlated with a decreased risk for developing diseases in the central nervous system. Astrocytes are important immune cells and contribute toward inflammation during neurological diseases. The vitamin D receptor has been reported to be expressed in astrocytes; however, the effect of vitamin D3 on astrocyte activation has not been studied. Here, we found that lipopolysaccharide stimulation in astrocytes could enhance the expression of vitamin D receptor and Cyp27B1, which encodes the enzyme for converting vitamin D3 into its active form. Vitamin D3 suppressed the expression of proinflammatory cytokines tumour necrosis factor-α, interleukin-1β, vascular endothelial growth factor, and also TLR4 in activated astrocytes. Astrocyte activation was further found to be suppressed after the administration of vitamin D3 in neonatal rats injected with lipopolysaccharide in vivo. We demonstrated the antiactivation effect of vitamin D3 in astrocytes after lipopolysaccharide stimulation. Considering the function of reactive astrocytes in augmenting inflammatory response in neurodegeneration and brain injury, the finding that vitamin D3 administration may inhibit astrocyte activation may be potentially useful for the treatment of central nervous system disorders.

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To improve the improve the management and matching of 3D printing resources, a 3Dprinting cloud platform based on dynamic service composition technology is established, and the 3D printing composite service is optimized. First, cloud computing is combined with 3D printing to establish cloud manufacturing mode. According to the characteristics of each stage, the dynamic service composition technology under cloud manufacturing mode is divided into three stages. Then, dynamic service composition technology of 3D printing resource is established. Based on the logical relationship between services, breadth algorithm and depth algorithm are used to find the optimal service composition path in the search graph to meet the different needs of users. The experimental results show that the relationship between user requirements and services can be obtained by calculating the quality of service. In the case, the service quality required by users is less than 20, and service 1 and 3 can meet the needs of users. This exploration provides a reference for the study of 3D printing resources dynamic service composition.