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Very low concentrations of histones stimu-guanidine, 2,4-dinitrophenol, and oligomycin). The late the release of K+ from mitochondria by an energy-phenomenon is also inhibited by chlorpromazine, dependent process. Either electron transport or adeno-atractyloside, and the divalent cations, Mg2+, Sr2+, sine triphosphate can serve as the energy source. The and Mn2+. Inorganic phosphate, in concentrations histone-induced K+ efflux is blocked by inhibitors of significantly lower than that required for oxidative electron transport (antimycin A, cyanide, and amytal) phosphorylation, is necessary for optimal histoneor by energy-transfer inhibitors or uncouplers (octyl-induced Kf efflux.

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