No abstract

Metabolism is an essential function that maintains the cooperation and homeostasis of physiological constituent tissues of internal organs. Homeostasis to external stimuli is provided by endocrine and nervous systems. Cytokine is a protein produced and secreted by immune cells such as inflammation and other immune changes. The production and secretion of cytokines are regulated by neuromodulators. Damage to metabolic function, loss of function. Therefore, if the metabolic activity such as immune function is abnormal, a disease can occur. In this study, we developed a portable medical device having a microbioprocessor-based energy-efficient biofeedback stimulation system that could support nerve detection and stimulation using two stable wireless connections with a high-efficiency power management and wireless charging for electronic drug applications. Digital variable optimization and programmed current driver with 180 nm HV BCD technology were used to implement closed loops in leobase current (IRh), clonal time (TCh), and fire resistance (TRefractory) based on neuronal characteristics. Such a small implant battery in closed-loop therapy operates at an average of 80 μW a single charge. The closed-loop can effectively stimulate variables such as amplitude, pulse width, frequency, and driver power.