The homogenously rhodium-catalyzed tandem reaction of the hydroaminomethylation of 1-decene is investigated in a thermomorphic solvent system consisting of methanol and n-dodecane with the ligand sulfoxantphos. The influence of temperature, pressure and catalyst concentration is studied experimentally as the basis for kinetic modeling and parameter estimation. A kinetic model for the hydroaminomethylation is developed by connecting and reparametrizing a mechanistic approach for the hydroformylation with a reductive amination model. Simulations and experimental data are in good agreement indicating the transferability of mechanistic kinetic models.
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