Emotions understanding has acquired a significant interest in the last few years because it has introduced remarkable services in many aspects regarding public opinion mining and recognition in the field of marketing, seeking product reviews, reviews of movies, and healthcare issues based on sentiment understanding. This conducted research has utilized the issue of Omicron virus as a case study to implement a emotions analysis framework to explore the global attitude and sentiment toward Omicron variant as an expression of Positive feeling, Neutral, and Negative feeling. Because since December 2021. Omicron variant has gained obvious attention and wide discussions on social media platforms that revealed lots of fears and anxiety feeling, due to its rapid spreading and infection ability between humans that could exceed the Delta variant infection. Therefore, this paper proposes to develop a framework utilizes techniques of natural languages processing (NLP) in deep learning methods using neural network model of Bidirectional-Long-Short-Term-Memory (Bi-LSTM) and deep neural network (DNN) to achieve accurate results. This study utilizes textual data collected and pulled from the Twitter platform (users’ tweets) for the time interval from 11-Dec.-2021 to 18-Dec.-2021. Consequently, the overall achieved accuracy for the developed model is 0.946%. The produced results from carrying out the proposed framework for sentiment understanding have recorded Negative sentiment at 42.3%, Positive sentiment at 35.8%, and Neutral sentiment at 21.9% of overall extracted tweets. The acquired accuracy using data of validation for the deployed model  is 0.946%.