VERA, W.; MORA, H.; LAYA, M. S.; BEDOYA, L.; CABRERA, E. V.; J. Sci. Ind. Res. 65 (2006) 4, 299-308; Cent. Quim., Inst. Venez. Invest. Cient., Caracas 1020-A, Venez.; Eng.) -Lindner 33-282

The data on the use of silica gel in organic synthesis are The data on the use of silica gel in organic synthesis are presented. Some specific features of cyclisation (both intra-and presented. Some specific features of cyclisation (both intra-and intermolecular) reactions, rearrangements, reduction, oxidation, intermolecular) reactions, rearrangements, reduction, oxidation, condensation, formylation, hydration and dehydration, protec-condensation, formylation, hydration and dehydration, protection of functional groups, tion of functional groups, etc etc., in the presence of silica gel, are ., in the presence of silica gel, are discussed. The bibliography includes 96 references discussed. The bibliography includes 96 references. .

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The transformations of 5-methoxy, 6-methoxy and 7-methoxy-a-tetralones are described. Studies on the synthesis of diterpenes veadeiroic acid 12, triptolide 18, sesquiterpenes biflorin 25, mansonone F 26, cacalol 39 and a potential intermediate for 11-deoxydaunomycinone 59 from 5-methoxy-a-tetralone 1 are discussed. Several intermediates for diterpenoid compounds and a total synthesis of phytoalexin orchinol 53 from 6-methoxy-a-tetralone 2 have been accomplished. 7-Methoxy-a-tetralone 3 has proved to be a suitable starting material for a simple and short synthesis of cadinene dihydrochloride 45.

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