This study aims to address the knowledge gap in supply chain management between large corporations and small and medium enterprises by investigating the ambidexterity of supply chain management in small and medium enterprises. The study also focuses on the integration of knowledge management, user satisfaction, and supply chain management ambidexterity as its main novelty. A quantitative empirical technique was used, utilizing online data collection evaluated through partial least squares analysis with a sample of 372 reliable data points. This study presents five hypotheses, and the results of the Smart PLS 4 analysis indicate that all four theories have positive and significant influences. In addition, the results can be used for research in supply chain management and knowledge management, as well as for making plans to improve the quality of managed organizations. Doi: 10.28991/HEF-2022-03-03-08 Full Text: PDF