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Methods for the synthesis of esters and amides of edeine A were developed and a number of derivatives of this type was obtained and characterized. The antimicrobial activities of the derivatives are comparable to the activity of the native antibiotic and indicate that the

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An efficient synthesis of selectively protected (2S)-1,2,4-triaminobutane from L-glutamic acid via (2S)-N 4 -benzyloxycarbonyl-2,4-diaminobutanamid is described.