Abstract:The mosquito Aedes aegypti is a vector that carries the arboviroses responsible for dengue and dengue hemorrhagic fevers, diseases which are considered as major worldwide public health problems. The most widely adopted strategy for decreasing the incidence of these diseases resides in controlling the mosquito larvae population. The increasingly incidence of resistant mosquito populations due to the continuous use of synthetic insecticides, in addition to the public concern over environmental pollution and toxicity of the current commercial pesticides to nontarget organisms, have stimulated the search for alternative methods for mosquito control. In this regard, plant-derived compounds have emerged as a promising efficient and environmentally safe tool for reducing the larval population of Aedes aegypti mosquitoes. This review provides a survey on naturally occurring plant compounds belonging to different classes of secondary metabolites which have been shown to be active against Aedes aegypti.Keywords: Dengue; larvicidal compounds; bioactive natural products; Aedes aegypti. ResumoO mosquito Aedes aegypti é o vetor que transmite as arboviroses responsáveis pela dengue e a dengue hemorrágica, doenças consideradas um importante problema de saúde pública mundial. A estratégia mais amplamente adotada para diminuir a incidência dessas doenças consiste em controlar a população de larvas do mosquito. A ocorrência cada vez maior de populações resistentes de mosquitos, devido ao uso contínuo de inseticidas sintéticos, além da poluição ambiental e toxicidade dos pesticidas comerciais atualmente em uso a organismos não-alvo, tem estimulado a procura por métodos alternativos para o controle do mosquito. Neste sentido, compostos de origem vegetal surgem como uma estratégia promissora, eficiente e ambientalmente segura para reduzir a população de larvas de mosquitos Aedes aegypti. Esta revisão trata de pesquisas sobre compostos naturais originados de plantas pertencentes a diferentes classes de metabólitos secundários, que mostraram atividade contra larvas de Aedes aegypti.Palavras-chave: Dengue; substâncias larvicidas; produtos naturais bioativos; Aedes aegypti.
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