ABSTRAKPenelitian ini bertujuan untuk mencari alternatif pencegahan penyakit avian influenza (AI) pada ayam pedaging melalui peningkatan daya tahan tubuh. Limfosit T akan bereaksi secara langsung melawan antigen yang telah dipresentasikan ke permukaan sel oleh antigen presenting cell (APC). Interaksi Th-CD4 berperan membantu mampertahankan ikatan Th-APC agar tetap menyatu pada saat aktivasi antigen spesifik berlangsung. Asam lemak pada virgin coconut oil (VCO) berpotensi sebagai immunostimulan sehingga mampu meningkatkan daya tahan tubuh ayam melalui peningkatan limfosit T dan Th-CD4. Penelitian ini menggunakan 40 ekor ayam broiler umur satu hari. Desain penelitian yang digunakan adalah Rancangan Acak Lengkap pola faktorial dengan faktor pertama adalah 2 level vaksin yaitu kelompok ayam yang divaksin AI dan kelompok ayam yang tidak divaksin AI. Faktor kedua menggunakan 4 level VCO yaitu 0, 5, 10 dan 15 mL/kg pakan. Ayam broiler dikelompokkan dalam 8 kelompok perlakuan dan dilakukan pengulangan dalam 5 unit percobaan. Pakan dan minum diberikan ad libitum selama 4 minggu. Hasil penelitian menunjukkan bahwa jumlah limfosit dan Th-CD4 pada ayam yang diberi VCO sebesar 10 mL/kg pakan dan divaksin AI lebih tinggi dibanding pemberian VCO tanpa divaksin AI.Kata kunci: avian influenza, ayam pedaging, CD4, limfosit, VCO ABSTRACTThis research aimed to find preventing alternative of avian influenza (AI) disease in broiler chicken by increasing body immune. Lymphocyte T would directly react to antigen presented to the cell surface by antigen presenting cell (APC). Th-CD4 interaction functioned to maintain Th-APC bond intact during specific antigen activation. Fatty acid in virgin coconut oil (VCO) was potential as immunostimulant, which therefore could increase chicken immunity through the increase of lymphocyte T and Th-CD4. This research used 40 one-day-old broiler chickens. The method applied was Completely Randomized Factorial Design in which the first factor was two levels of vaccine, namely groups of AI vaccinated and unvaccinated. The second factor was four levels of VCO namely 0, 5, 10, 15 mL/kg feed. Day Old Chick (DOC) were divided into eight treatment groups and repeated five times. Feed and water were given ad libitum for four weeks. The result showed that the number of lymphocyte and Th-CD4 in chickens given 10 mL per kg feed and vaccinated with AI was higher than that in chickens given VCO without AI vaccine.
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