This study determines the effect of motivation to learn, the ability of teachers to teach, parental attention and learning facility on the understanding of the regulatory system materials of students of grade XI Senior High School. The study population were students of grade XI Senior High School all area of Gunungkidul, the respondent taken for this study were 272 students. The analysis of the was done by using descriptive analysis and multiple linear regression analysis with SPSS 20 for windows. The result of the study showed that the effect of learning motivation is 9.4%; the ability of teachers to teach is 9.5%; parental attention is 12.1% and learning facilities is 7.6% towards the understanding of the regulatory system materials and simultaneously affect at 20.3% on the understanding of the regulatory system material.
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