The chloride diffusion coefficient of concrete is time dependent. The high performance concrete (HPC) was prepared and the specimens were tested by ASTM C1202 and the durability of HPC in long period is analyzed with the time dependency of diffusion in this paper. The results show that the chloride diffusion coefficients of the HPC with only fly ash are large than those of the HPC with multi-admixtures, but the attenuation of the chloride diffusion coefficients of the formers are faster than the latters. The analysis results show that the chloride concentrations in concrete is over estimated when time-dependence of chloride diffusion is not considered, and the durability of concrete in long period is determined by both chloride diffusion coefficient and age factor.