Objective:To observe the effect of Aralia echinocauIis Hand. Mazz capsula-2 on the treatment of knee osteoarthritis．Method: 90 cases of knee osteoarthritis (Male 50 cases / Female 40 cases) were collected in 2013 and 2014, and they were divided into three groups. 35 persons (Male 20 cases / Female 15 cases) in treatment group-1 received Aralia echinocauIis Hand. Mazz capsula-2,20 persons (Male 10 cases / Female 10 cases) in treatment group-2 received Aralia echinocauIis Hand. Mazz capsula-2 +finbid, 35 persons (Male 20 cases / Female 15 cases) in control group received finbid for 60 days in a course of treatment.Result: Compared with control group (91.43%), treatment group-1's effective rate (85.71%) was lower and treatment group-2's effective rate (95.00%) was higher, but the difference in different groups was no statistically significant (P＞0.05).Conclusion: Aralia echinocauIis Hand. Mazz capsula-2 in the treatment of knee osteoarthritis showed good efficacy, joint pain could be shortened.If patients were cured by finbid with Aralia echinocauIis Hand. Mazz capsula-2 together, they would get better clinical curative effect.