Background: Neonatal acute hematogenous osteomyelitis is very rare in clinical research. Early diagnosis and treatment to reduce the sequelae is very important. The purpose is to introduce a rare and special case to medical workers, so that readers know how to diagnose and treat such special cases. Methods: Through the clinical manifestations, imaging studies and the results in blood culture. Results: There were no adverse sequelae after effective antibiotics, which were discharged. Conclusion: There is great importance in early diagnosis and treatment of neonatal osteomyelitis.

The cases of coronavirusdisease 2019 in children have been increasing with the ongoing pandemic.The finding suggests children have mild symptoms and a short course of the disease. Angiotensinconverting enzyme-2 mediates entry of the virus into the cell, the combination of virus and ACE2 leads to an increase in activity of angiotensin II, resulting in acute injury to lungs, myocardium and other organs. The infection causes down-regulation of ACE2 expression. The ACE2 plays an important role in the infection progression and clinical characteristics of COVID-19. Works on ACE2 and virus spike protein have future prospects of strategic information on prevention, management as well as vaccine development.

Objective: Retrospective clinical analysis of adverse drug reactions in children. Methods: Clinical data analysis was performed on 844 cases of hospitalized children reported for adverse drug reactions. Results: Children under 3 y of age were more prone to the adverse drug reactions; adverse reactions were mainly caused by antibiotics and traditional Chinese medicine; intravenous rout was the most common mode of administration of drug causing adverse reaction; adverse drug reaction was mostly observed within 1 h of drug administration; most common clinical manifestation of adverse drug reactions was the skin damage. Conclusions: More attention should be paid towards rational use of drugs, to avoid multiple drug use as far as possible, and to focus on prevention of adverse drug reactions, timely detection if happened and immediate treatment. Establishment of drug reaction reporting system will definitely help the physicians across the globe to better understand the phenomenon.

COVID-19 has been known as the part of “epidemic disease” in TCM (Traditional Chinese Medicine). The reason is that the human body feels the external toxin and pathogen. The pathogenesis is mainly "wet, heat, poison, stasis, deficiency" and the lesions are the principal in the spleen, lungs, and stomach. There are 4 COVID-19 waves in South Africa including ancestral variants, Beta, Delta, and Omicron. Compared COVID-19 cases of the 4 waves and found the admission rate of Omicron was 4.9%, Delta was 13.7%, and Beta was 18.9% (P<0.001). It also found that 28.8% of inpatients of Omicron were critical patients, while critical inpatients of Beta, and Delta were 60.1% and 66.9% respectively (P<0.001). The infectivity of Omicron is ten times that of Delta.  Day on Jan 17, 2022, there were about 125 million omicron infections were diagnosed in the world. The current COVID-19 epidemic situation is frustrating. Today there are still no effective vaccines and targeted therapies for the treatment of COVID-19. Fight against the epidemic diseases in China, 90% of confirmed cases have been treated with TCD. TCD can effectively relieve symptoms, shorten the course of the disease, improve the cure rate, reduce the mortality rate, and promote rehabilitation, the total effective rate is more than 90%. This unique system of TCM has opened a new avenue to fight the novel pandemic.

Kawasaki shock syndrome is a severe disease that seriously affects cardiac in children . We need for early identification, timely and correct processing. This review of reference to eighteen international important literature, for the onset of KDSS, diagnosis and treatment, improve the level of diagnosis and treatment technology for KDSS.