Poor prognosis is associated with patients with metastatic colorectal cancer. To seek effective methods, we examine the efficacy and safety of bevacizumab plus FOLFIRI as a second-line chemotherapy in Chinese patients with metastatic colorectal cancer (mCRC). A total of 55 patients with previous failure of oxaliplatin-based chemotherapy were included in this study, from October 2010 to February 2012. All patients received bevacizumab (5 mg/kg) plus FOLFIRI every other week until disease progression or intolerable toxicity occurred. The response rate was 31%, and the disease-controlled rate was 76.4%. The median progression-free survival was 6 months, and the median overall survival was 17 months. Adverse events (AEs) related to chemotherapy were mild to moderate. Only the incidence of grade 3-4 neutropenia reached to 25.5%. The incidence of AEs related to bevacizumab was low. These AEs included grade 3-4 toxicities of hypertension and proteinuria 5.4 and 3.6%, respectively. Bevacizumab plus FOLFIRI is an effective and safe regimen as a second-line treatment for patients with mCRC in China.

In order to explore the factors of fraxinus mandshurica veneer dye-uptake, the discourse made use of reactive dyes. The result showed that significant effects of fraxinus mandshurica veneer dye uptake are reactive dye concentration, dyeing temperature, dyeing time and sodium chloride concentration. The artificial dyeing technology of fraxinus mandshurica was defined finally. Using reactive dyes, reactive red X-3B 10 g/L, temperature 95 °C, the dyeing time 240 min, sodium chloride 30 g/L. The study provided a theory gist and a practical guidance role for imitation precious wood.

Considering the demands for product ergonomics design, the paper proposed a driven design method for product’s shape and structure design through the manipulation of human body models. Based on the anthropometry data, a parametric human body driving model system is established with three layers, which are structure model, dimension model and surface model. The driven design method of product ergonomics design is realized, in which human body data are directly mapped to product design parameters. The driven design method provides a rational way to utilize ergonomics design principles and guarantee higher efficiency and more reliability. The method is tested in seat design examples.

An ergonomics optimization method of human-product contact surface design based on stochastic finite element was described. The shape of the contact surface between user and the product is the most complex content in product morphology design. Thinking of the individual needs of users, the stochastic finite element method was used to simulate the shape of product surface to meet the randomness of design variables, and the genetic algorithm was used to search the optimal surface solutions. And then a case of the seat back surface design of a driver chair was studied. The optimization results showed that the maximum pressure of the surface was decreased and the structure's reliability were guaranteed. The effectiveness of this ergonomics optimization method was verified.

The pulse position modulation, which has the advantage of average energy efficiency and bandwidth efficiency, is an attractive modulation scheme for free-space optical communication. An important practical issue is to employ an efficient channel coding to this modulation. In this view, we consider the use of low density parity-check code together with iterative soft demodulation and channel decoding at the receiver. In particular, we discuss the calculation of the soft information at the demodulator to accommodate the LDPC decoder. We show that the proposed scheme is quite efficient against demodulation errors due to the receiver noise.