Background: Plexiform neurofibroma (PN) is a subtype of neurofibroma that is rather uncommon in the clinic. Plexiform neurofibroma is usually associated with neurofibromatosis type I (NF1). Only very few patients have isolated PN, which means they have neither NF1 signs nor relevant family history. Solitary PN is extremely rare. There have been no instances of finger back PN or solitary PN all around the world, which could lead to misdiagnosis, missed diagnosis, and mistreatment. Case presentation: We present a rare case of a 50-year-old middleaged woman who experienced numerous postoperative recurrences of painful tumors on the dorsal side of her proximal middle finger on her right hand. Following surgery, the pathology diagnosis was PN. The pathology diagnosis after surgery was PN. After the operation, the wound healed in stage I, and the outcomes were satisfactory. Conclusion: In the dorsal finger nerve, solitary PN can occur. As a result, the differential diagnosis of NF1, PN, and isolated PN as hand masses is crucial for early diagnosis and rational treatment, especially for masses with pain associated with neuropathy should be considered as a possibility of this disease. The lesion may be invasive or multiple in character, Keep a close eye on cautious probing throughout the surgery. To reduce recurrence, to avoid further deterioration, and to alleviate patients’ agony and psychological strain, the lesion tissue must be entirely removed. Keywords: Plexiform neurofibroma; Solitary plexiform neurofibroma; Neurofibromas; Recurrence; Case report.