Aculeatin A, isolated from the plant Amomum aculeatum, is a dispirocyclic compound having antimalarial activity. We describe a novel synthetic approach to aculeatin A via a stepwise strategy.

Abstract. One concise methods for synthesis of oxetan-3-ol from epoxy chloropropane are reported. The method involve employsepoxy chloropropane opening of reaction, esterifiction, electrophilic reaction, ring-closure reaction.

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Synthetic study of the intermediate of (+)-vertine and (+)-lythrine, benzyl-2-(1methoxy-1,3-dioxobutan-2-yl) piperidine-1-carboxylate was described, which included protection, reduction and addition of silyl enol ether.