Tim-3 displays critical roles in microenvironment-induced activation and protumoral effects of TAMs in HCC. Interference of Tim-3 might be great potential in HCC therapy.

This paper presents a new method for computing the discriminant vectors of the Foley–Sammon optimal set. First, an equivalent criterion is presented to replace the Fisher criterion; then, the problem of computing the discriminant vectors in Rn is transformed into the maximum problem in a subspace. Several theorems relating to the method are also presented. Experimental results show that the present method is superior to the positive pseudoinverse method, and the perturbation method in terms of correct classification rate.

We propose a new strategy to design broadband and wide angle diffusion metasurfaces. An anisotropic structure which has opposite phases under x- and y-polarized incidence is employed as the “0” and “1” elements base on the concept of coding metamaterial. To obtain a uniform backward scattering under normal incidence, Simulated Annealing algorithm is utilized in this paper to calculate the optimal layout. The proposed method provides an efficient way to design diffusion metasurface with a simple structure, which has been proved by both simulations and measurements.

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