No abstract

A novel Ru(0)- and Rh(I)-catalyzed noncarbonylative and carbonylative cycloisomerization of readily available 3-alkynyl imine derivatives has been developed to provide 3,4-fused or nonfused pyrrole derivatives efficiently in moderate to excellent yields. The key steps involve the formation of a ruthenium carbenoid intermediate or a rhodacycle intermediate, respectively. In these reactions, CO can serve as a ligand or a reagent.

An analogue of nicotinamide adenine dinucleotide (NAD+) featuring an azido group at 3′-OH of adenosine moiety is found to possess high specificity for human PARP1-catalyzed protein poly-ADP-ribosylation.

A novel asymmetric [4+2] annulation of vinyl ketones with oxindole-derived a,b-unsaturated imines has been developed in the presence of a multifunctional thiourea-phosphine catalyst derived from a natural amino acid, providing the first phosphine-catalyzed enantioselective synthesis of 2',3'dihydro-1'H-spiro[indoline-3,4'-pyridin]-2-ones in good yields with excellent stereoselectivities under mild conditions.