Objective:To investigate the involvement of human leukocyte antigen (HLA) loci in aromatic antiepileptic drug–induced cutaneous adverse reactions.Methods:A case-control study was performed to detect HLA loci involved in aromatic antiepileptic drug–induced Stevens-Johnson syndrome in a southern Han Chinese population. Between January 1, 2006, and December 31, 2015, 91 cases of Stevens-Johnson syndrome induced by aromatic antiepileptic drugs and 322 matched drug-tolerant controls were enrolled from 8 centers. Important genotypes were replicated in cases with maculopapular eruption and in the meta-analyses of data from other populations. Sequence-based typing determined the HLA-A, HLA-B, HLA-C, and HLA-DRB1 genotypes.Results:HLA-B*15:02 was confirmed as strongly associated with carbamazepine-induced Stevens-Johnson syndrome (p = 5.63 × 10−15). In addition, HLA-A*24:02 was associated significantly with Stevens-Johnson syndrome induced by the aromatic antiepileptic drugs as a group (p = 1.02 × 10−5) and by individual drugs (carbamazepine p = 0.015, lamotrigine p = 0.005, phenytoin p = 0.027). Logistic regression analysis revealed a multiplicative interaction between HLA-B*15:02 and HLA-A*24:02. Positivity for HLA-A*24:02 and/or HLA-B*15:02 showed a sensitivity of 72.5% and a specificity of 69.0%. The presence of HLA-A*24:02 in cases with maculopapular exanthema was also significantly higher than in controls (p = 0.023). Meta-analysis of data from Japan, Korea, Malaysia, Mexico, Norway, and China revealed a similar association.Conclusions:HLA-A*24:02 is a common genetic risk factor for cutaneous adverse reactions induced by aromatic antiepileptic drugs in the southern Han Chinese and possibly other ethnic populations. Pretreatment screening is recommended for people in southern China.

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The paper carried out comparative studies on the workability, mechanical properties and chloride permeation resistance of wollastonite micro fiber mortar and alkali resistant glass fiber（ARGF） mortar. The results show that the mechanical properties and chloride permeation resistance of wollastonite micro fiber mortar improve significantly. The mechanical properties of wollastonite micro fiber mortar have greater advance in 90°C humidity. The SEM analysis results show that wollastonite micro fiber can form three-dimensional skeleton in the mortar, and combine closely with cement hydration products. This can make the structure of hardened paste denser and lead to excellent properties of mortar. Meanwhile, the compressive strength of wollastonite micro fiber mortar with wollastonite micro fiber content 30%(by mass) is close to ARGF mortar with ARGF content 1.5% (in volume), but the chloride permeation resistance of wollastonite micro fiber mortar is much better.

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In present paper, the effectiveness of local mean decomposition (LMD) method to signals of fault gears, which are multi-component amplitude modulated and frequency modulated, is demonstrated. A series of tests on wearing and broken tooth of gears are conducted. And the fault characteristics extracted by Fourier transform, Hilbert transform and LMD are compared. The results validate that LMD method is an effective way to extract the characteristics of fault gears and improve the accuracy of fault diagnosis of gears since it is able to reduce effect of false components.