Research on the interaction mechanism of drugs with DNA is essential to understand their pharmacokinetics. The interaction between rare earth complexes Pr(DNR)3 and Herring-Sperm DNA was studied in Tris-HCl buffer solution (pH 7.4) by absorption and fluorescence spectroscopy and viscosity measurements. The results showed that the modes of interaction between Pr(DNR)3 and Herring-Sperm DNA were electrostatic and intercalation. The binding ratio was nPr(DNA)3 ׃ nDNA = 5׃1 and the binding constant was KΘ292K = 4.34×10exp3 L mol-1. Furthermore, according to the double reciprocal method and the thermodynamic equation, the intercalative interaction was cooperatively driven by an enthalpy effect and an entropy effect

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