A novel, label-free liquid crystal biosensor for the detection of Parkinson disease related alpha-synuclein based on DNA aptamer was constructed.

The elusive hydrogen-bonded sulfur monoxide–hydroxyl radical complex (•OH···OS), a missing intermediate in the atmospheric chemistry of SO2, was generated in the 266 nm laser photolysis of the sulfinyl radical HOSO• in cryogenic Ar-matrixes. In addition to the IR spectroscopic characterization with deuteration, its thermal conversion to HOSO• with an activation barrier of 0.33 ± 0.11 kcal mol–1 (calcd 0.32 kcal mol–1, CCSD­(T)-F12a/AVTZ) in the temperature range of 15.0–21.0 K and a H/D kinetic isotope effect of 2.4 at 16.0 K have been observed.

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