Tpm4-tv1 is a heart-specific isoform of Tpm4 and is essential for heartbeat in zebrafish embryos.

Background: Sec13 is a core component in both the protein trafficking complex and the nuclear pore complex (NPC). Results: The role of Sec13 in retina development has been investigated. Conclusion:The NPC function of Sec13 is essential for retina development. Significance: This is the first genetic evidence to differentiate the contributions of the two functions of Sec13 during organogenesis.

Background: Nupl07 is an important component of nuclear pore complexes, but its developmental roles remain elusive. Results: Zebrafish zygotic nup107 mutant embryos show tissue-specific defects with impaired nuclear export of mRNAs. Conclusion: Nup107 plays an essential role in development of vertebrate embryos. Significance: This study provides the first vertebrate model to elucidate Nup107 function in embryonic development.