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Hepatocellular carcinoma (HCC), one of the most common malignant tumors in China, severely threatens the life and health of patients. In recent years, precision medicine, clinical diagnoses, treatments, and innovative research have led to important breakthroughs in HCC care. The discovery of new biomarkers and the promotion of liquid biopsy technologies have greatly facilitated the early diagnosis and treatment of HCC. Progress in targeted therapy and immunotherapy has provided more choices for precise HCC treatment. Multiomics technologies, such as genomics, transcriptomics, and metabolomics, have enabled deeper understanding of the occurrence and development mechanisms, heterogeneity, and genetic mutation characteristics of HCC. The continued promotion and accurate typing of HCC, accurate guidance of treatment, and accurate prognostication have provided more treatment opportunities and prolonged survival timelines for patients with HCC. Innovative HCC research providing an in-depth understanding of the biological characteristics of HCC will be translated into accurate clinical practices for the diagnosis and treatment of HCC.

To improve the tribological performance of CSS-42L bearing steel, smooth surfaces (SSs), groove-textured surfaces (GSs), GSs with Sn-Ag-Cu (GSs-SAC), and GSs with Sn-Ag-Cu-Ti3C2 (GSs-SACT) were prepared on CSS-42L. In addition, experimental studies were conducted on tribological properties. The obtained results indicated that GSs-SACT exhibited the best anti-friction and noise reduction performances. These remarkable tribological performances were attributed to the synergistic effects of grooves, Sn-Ag-Cu, and MXene-Ti3C2. The inconsistent rules of frictional forces were improved by the grooves and SACT, which inhibit the friction-induced noise. The micro-nano size-effects of MXene-Ti3C2 enhanced the repairing effect and anti-friction property of composite lubricants, which improved the profile characteristics of GSs-SACT.

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