A dehydrogenative
annulation of 2-arylindazoles with maleimides
for the switchable synthesis of indazolo[2,3-a]pyrrolo[3,4-c]quinolinones or spiroindolo[1,2-b]indazole-11,3′-pyrrolidinones
is presented. Mechanistically, the formation of the title compounds
involves a Rh(III)-catalyzed C–H metalation of 2-arylindazole,
followed by maleimide insertion and intramolecular cyclization. Interestingly,
the selectivity to form the fused or spiro compounds could be switched
by resorting to different additives. The notable features of this
protocol include simple substrates and excellent atom economy and
regioselectivity.
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