Easy cancer recurrence and wound infections have been clinical challenges after surgical treatment of melanoma. Herein, a silk‐inspired in situ gelation system containing methacrylated silk fibroin (SF) and chlorine e6 for improved cancer therapy with enhanced wound healing is developed. Favored by the macrophage recruitment capacity of the SF hydrogel, promising antitumor immune responses can be turned “on” via near infrared irradiation in a controllable manner to achieve combination therapy with photodynamic therapy to significantly suppress melanoma recurrence. Moreover, the effective photodynamic antibacterial activity of this bioactive system with the capacity of light‐controllable modulating macrophage phenotype promotes remarkable tissue ingrowth with hair follicle regeneration for Staphylococcus aureus infected wound healing. Thus, this multifunctional silk‐based hydrogel system, as a desirable wound dressing, provides a new platform for promising melanoma therapy and skin regeneration.

Organic/inorganic hybrid perovskite solar cells (PeSCs) have been of great interest due to their easy fabrication and high power conversion efficiency (PCE) exceeding 25%. [1-4] Nevertheless, hybrid perovskites (PVKs) suffer from low thermal stability due to the volatile nature of organic cations (i.e., methylamine), [5] which limits the commercial applications of hybrid PeSCs. [6,7] Thus, inorganic cations such as Cs þ are used to replace organic cations, [8] yielding all-inorganic PVKs with considerably improved thermal stability. [9,10] Among various Cs-based inorganic PVKs, dual-halide PVKs of CsPbI 2 Br feature a suitable bandgap (E g) of around 1.9 eV and reasonable phase stability, [11] which make it a promising photoabsorber. To date, champion PCEs of 17.03% and 15.92% have been achieved for n-i-p-type (normal) and p-in (inverted)-type PeSCs, respectively, both based on CsPbI 2 Br. [12-18] Nevertheless, such PCE values are still lower than those of hybrid PeSCs. Further improvement is highly demanded for all-inorganic PeSCs. It has been well recognized that solution-processed inorganic PVK films, especially those prepared at a low temperature, are highly defective, [19] which usually result in large energy loss in PeSCs. For example, the highest reported open-circuit voltages (V OC) are 1.40 and 1.27 V for normal and inverted CsPbI 2 Br PeSCs, [15,16] respectively, both much lower than the E g (%1.9 eV) of PVK. Such large energy loss might be attributed to the severe defect-induced nonradiative recombination. [20,21] In addition, high-density interfacial defects also lead to poor contact between the PVK and electrode, which increases device series resistance and reduces short-circuit current density (J SC) and fill factor (FF). [21] To minimize the bulk and interfacial defects associated with inorganic PVKs, a variety of passivation strategies have been used, [21-28] including additive engineering and post-treatment. Nevertheless, most strategies focus on the passivation of either bulk or interfacial defects rather than both. On the other hand, considerable efforts have been devoted to maximizing the built-in electric field (BEF) of PeSCs, which facilitates carrier separation/transport and hence contributes to the V OC of the device. As the BEF is primarily determined by the work function difference between the two electrodes or transport layers (i.e., electron transport layer [ETL] and hole transport layer [HTL]), [29] BEF enhancement still remains

By combination of alginate/polyacrylamide/chitosan, tough antibacterial hydrogels are designed for applications as tissues adhesives to promote wound healing.

A lack of effective bioactivity to create a desirable microenvironment for peripheral nerve regeneration has been challenging in successful treatment of long-distance injuries using nerve guidance conduits (NGCs) clinically. Herein, we developed a silk-inspired phototriggered gelation system combining dual therapeutic cues of anisotropic topography and adhesive ligands for improving peripheral nerve regeneration. Importantly, enhanced cell recruitment and myelination of Schwann cells were successfully achieved by the Arg-Gly-Asp (RGD)-peptide-immobilized hydrogel scaffolds to promote axon growth. Moreover, as the orientated growth of Schwann cells and rapid axon growth were facilitated by aligned grooved micropatterns, this multifunctional bioactive system provides remarkable nerve regeneration with function recovery for long-distance nerve injury. Therefore, this bioengineered silk-inspired nerve guidance conduit delivers a platform for desirable peripheral nerve repair.