Highlights d Human b cell dysfunction induced by metabolic stress may be persistent or transient d Specific transcriptomic changes associate with durable or reversible damage d Type 2 diabetes (T2D) b cells have several functional and molecular alterations d T2D and irreversibly or temporarily impaired b cells share key transcriptome traits

BS reduces the odds of some adverse maternal and fetal outcomes among obese women.

Domesticated buffaloes have been integral to rice-paddy agro-ecosystems for millennia, yet relatively little is known about the buffalo genomics. Here, we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals (132 swamp buffaloes and 98 river buffaloes) sampled from across Asia and Europe. Beyond the many actionable insights that our study revealed about the domestication, basic physiology and breeding of buffalo, we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior, digestion metabolism, strengths and milk production.

No abstract