A simple, effective, and direct alkylation and acylation of indazoles using aldehydes under metal-free conditions has been developed. This regioselective alkylation/acylation protocol can proceed under mild conditions, tolerate a wide range of functional groups, and deliver multifunctional 2H-indazole derivatives with high efficiency. Mechanism studies indicated that a radical process was involved.

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A novel and efficient approach for the amine-directed dehydrogenative C­(sp2)–C­(sp3) coupling of arylamines with acetonitrile was reported by using FeCl2 as the catalyst. Substituted anilines, aminopyridines, naphthylamines, and some nitrogen-containing heterocyclic arylamines react with inactive acetonitrile to form the corresponding arylacetonitriles in moderate to good yields. This protocol features nontoxic iron catalysis, efficient atom economy, nonprefunctionalized starting materials, good regioselectivity, and excellent compatibility of functional groups and aromatic rings, providing a novel, straightforward, and green approach toward arylacetonitriles.

A Mn (II)-catalyzed efficient C−H alkylation of imidazoheterocycles with methyl ketones has been developed via dehydrogenative C(sp3)-C(sp2) coupling which can serve as a novel approach toward hydrocarboxylated imidazolopyridines. The merit...

A simple strategy for the synthesis of 3-substituted Quinoxalin-2(1H)-ones containing ether units is proposed. The method is realized by the three-component synthesis of Quinoxalin-2(1H)-ones, styrenes and tert-Butyl peroxybenzoate (TBPB). This reaction has good functional group tolerance and may involve a free radical process.