Review question / Objective: The main purpose of this scheme is to analyze and evaluate the effect on MS symptoms, quality of life, and improvement of mental state through strict literature aerobic training and the movement of resistance training, and to compare aerobic training, resistance training, and the combination of aerobic and resistance training through network meta-analysis, select the best scheme of intervention, and provide a reference for clinical and evidence-based guidelines. Information sources: Randomized controlled trials of exercise therapy for MS were searched in the PubMed, Web of Science, Embase, Cochrane Library, CNKI, Wanfang Data Knowledge Service Platform, VIP, and CBM databases.