As a multi-particle entangled state, the Greenberger–Horne–Zeilinger (GHZ) state plays an important role in quantum theory and applications. In this study, we propose a flexible multi-user measurement-device-independent quantum key distribution (MDI-QKD) scheme based on a GHZ entangled state. Our scheme can distribute quantum keys among multiple users while being resistant to detection attacks. Our simulation results show that the secure distance between each user and the measurement device can reach more than 280 km while reducing the complexity of the quantum network. Additionally, we propose a method to expand our scheme to a multi-node with multi-user network, which can further enhance the communication distance between the users at different nodes.

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